{"id":4199,"date":"2017-10-29T07:10:55","date_gmt":"2017-10-29T14:10:55","guid":{"rendered":"http:\/\/sd41blogs.ca\/ignasv\/?p=4199"},"modified":"2017-10-29T07:18:11","modified_gmt":"2017-10-29T14:18:11","slug":"question-show-become-a-questioning-allstar-and-submit-your-science-question-to-be-answered-by-an-expert","status":"publish","type":"post","link":"http:\/\/sd41blogs.ca\/ignasv\/2017\/10\/29\/question-show-become-a-questioning-allstar-and-submit-your-science-question-to-be-answered-by-an-expert\/","title":{"rendered":"Question Show – become a questioning Allstar and submit your science question to be answered by an expert"},"content":{"rendered":"

Do you have questions?  Science questions anyone?  Submit your science questions to Quirks and Quarks and have a science expert answer your questions.<\/span><\/a><\/h3>\n

Questions can be submitted online via this link<\/span><\/a><\/h4>\n

 <\/p>\n

Learn more about Canada’s Top Science Show – How the Zika Virus mutated and became a terrifying Plaque<\/a><\/p>\n

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Abstract<\/h2>\n

Zika virus (ZIKV) has evolved into a global health threat due to its unexpected causal link to microcephaly. Phylogenetic analysis reveals that contemporary epidemic strains have accumulated multiple substitutions from their Asian ancestor. Here, we show that a single serine to asparagine substitution (S139N) in the viral polyprotein substantially increased ZIKV infectivity in both human and mouse neural progenitor cells (NPCs), led to more significant microcephaly in the mouse fetus, and higher mortality in neonatal mice. Evolutionary analysis indicates that the S139N substitution arose before the 2013 outbreak in French Polynesia and has been stably maintained during subsequent spread to the Americas. This functional adaption makes ZIKV more virulent to human NPCs, thus contributing to the increased incidence of microcephaly in recent ZIKV epidemics.<\/span><\/h5>\n<\/div>\n
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly<\/div>\n
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  1. Ling Yuan<\/span>1<\/sup><\/a>,<\/span>2<\/sup><\/a>,<\/span>*<\/a>,<\/li>\n<\/ol>\n

    <\/b> See all<\/span> authors and affiliations<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/header>\n

    Science <\/cite> 28 Sep 2017:
    \neaam7120
    \nDOI: 10.1126\/science.aam7120<\/div>\n","protected":false},"excerpt":{"rendered":"

    Do you have questions?  Science questions anyone?  Submit your science questions to Quirks and Quarks and have a science expert answer your questions. Questions can be submitted online via this link   Learn more about Canada’s Top Science Show – … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":519,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/posts\/4199"}],"collection":[{"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/users\/519"}],"replies":[{"embeddable":true,"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/comments?post=4199"}],"version-history":[{"count":7,"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/posts\/4199\/revisions"}],"predecessor-version":[{"id":4206,"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/posts\/4199\/revisions\/4206"}],"wp:attachment":[{"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/media?parent=4199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/categories?post=4199"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sd41blogs.ca\/ignasv\/wp-json\/wp\/v2\/tags?post=4199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}